73 Capecitabine-Induced Hypertriglyceridemia
نویسندگان
چکیده
منابع مشابه
Capecitabine-induced hypertriglyceridemia: a report of two cases.
BACKGROUND Capecitabine is a tumor-activated oral fluoropyrimidine with established antitumor activity in breast and colorectal cancer. Hypertriglyceridemia associated with this drug has rarely been reported in the literature. CASE REPORT This is a report of two patients who developed capecitabine-induced severe hypertriglyceridemia, together with an increase in total cholesterol levels. The ...
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The detailed pathophysiological mechanisms involved in the progression of hypertriglyceridemia to pancreatitis are little known. Using an animal model we have found that the earliest detectable changes caused by hypertriglyceridemia consist of a selective degeneration of the mitochondria in the exocrine pancreas cells. This supports the view that an excess of free fatty acids deranges the mitoc...
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Capecitabine, an oral prodrug of 5-fluorouracil (5-FU), is approved for early-stage and advanced colorectal cancer and metastatic breast cancer. Cardiotoxicity of 5-FU is well described in the literature. However, cardiac adverse effects of capecitabine are poorly described. We report a case of coronary vasospasm induced by capecitabine. A 41-year-old female with metastatic breast cancer presen...
متن کاملHypertriglyceridemia independent propofol-induced pancreatitis.
CONTEXT Propofol can cause acute pancreatitis related to hypertriglyceridemia, however, other mechanisms may also exist. CASE REPORT A 71-year-old male on propofol infusion in the intensive care setting, developed acute pancreatitis as confirmed biochemically and by imaging. He did not have any elevation of triglycerides and on propofol re-challenge, had recurrence of pancreatitis with the ab...
متن کاملPEG-asparaginase induced severe hypertriglyceridemia.
Asparaginase (ASP) is an effective chemotherapy agent extensively used in children with acute lymphocytic leukemia (ALL). There has been a recent interest in using ASP in adults with ALL, particularly the less toxic pegylated (PEG) formulation. Hypertriglyceridemia (HTG) is a rare complication of PEG-ASP therapy. We report two cases of obese patients who developed severe HTG after receiving PEG...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2018
ISSN: 0002-9173,1943-7722
DOI: 10.1093/ajcp/aqx149.442